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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

10.1111/adb.12583 27 HernandezN

If the alcohol benefit requires the maximum dose, then side effects, cost, and access all become part of the calculation for anyone considering it for that purpose

Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects