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10.3 Perspectives: from a single drug to an adaptive precision-care paradigm Future progress in this field will depend not only on more effective agents, but also on higher-quality reproductive evidence and better integration of metabolic, reproductive, and safety endpoints into clinical pathway design

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Given the increasing evidence of alternative receptor-independent sources of cAMP (from intracellular sAC) (29, 30), we hypothesized that GLP-1(2836) mediates its GLP-1Rindependent effects through sAC