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In males, high melatonin doses (100 mg daily) potentiate testosterone-induced LH suppression, and a negative correlation between nocturnal serum LH and melatonin have been reported (56, 57)

Therefore, the in-depth investigation of novel therapeutic targets and alternative interventions holds significant theoretical importance and clinical value for the prevention and treatment of NDDs

Sodium-glucose cotransporter-2 inhibitors increase the risk of diabetic ketoacidosis in adults with type 2 diabetes: should we be concerned in people without diabetes