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This is reassuring, but any significant mood changes, depression, anxiety, or suicidal thoughts should always be discussed with a healthcare professional immediately, regardless of what medications someone is taking

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People who expect smooth, linear progress are frequently frustrated during these transition periods and may make unnecessary changes to their diet or exercise in response to perceived stalls

For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank