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Since its approval in 1999 by the food and drug administration, Orlistat quickly became and remained a popular weight loss option due to how simple it is to use and its effectiveness in clinical trials

doi: 10.1007/s001250051560 51 LundgrenMSvenssonMLindmarkSRenstrmFRugeTErikssonJW

However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind

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