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Redox-active iron significantly accelerates lipid peroxidation events, whereas the glutathione-dependent antioxidant defence system, especially GPX4, is essential in inhibiting lipid peroxidation [78]

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Reactive oxygen species (ROS), pivotal to disease progression, are generated via multiple pathways, including TLR4-mediated NADPH oxidase (NOX) activation following macrophage infiltration [15]

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Kolbrich EA, Goodwin RS, Gorelick DA, Hayes RJ, Stein EA, Huestis MA (2008) Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults

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