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In the CY 2021 OPPS/ASC final rule with comment period (85 FR 86193), we codified the Overall Hospital Quality Star Rating methodology, including several methodology refinements, intended to improve the simplicity and predictability of measure emphasis within the methodology over time, and comparability of ratings among hospitals

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It is a partial sequence derived from a protein found in human gastric juice, which is one reason much of its early research focused on the gastrointestinal tract