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TLRs accomplish this feat in a process that goes something like this: You see, each species or strain of pathogen has its own unique structure or molecular pattern known as pathogen-associated molecular patterns or PAMPs As these pathogens make their way throughout your body, they inevitably bump into your cells including mast cells Your mast cells (and other immune cells) contain a variety of receptors capable of recognizing specific pathogen patterns including toll-like receptors When pathogens bump into mast cells' TLRs, these receptor sites essentially detect and latch onto the microbes' pathogen-associated molecular patterns Once a PAMP is bound to your mast cells' toll-like receptor, your cell releases molecules that launch your immune system into action and activate other immune cells Most microorganisms (including viruses, fungi, bacteria, and protozoa) express PAMPs meaning TLRs are able to sense just about any infection we might encounter

[19] [20] The rate and magnitude of glycemic deterioration depend on individual factors including baseline diabetes severity, duration of disease, beta-cell function, and lifestyle factors

(PubMed) Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM