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Six male rats (n = 3 with HFD, n = 3 with chow food) had electrodes implanted in their LH for electrophysiological recordings

(1) Studies on the Validation of In Vivo Obesity Intervention Effects A large number of in vivo animal experiments have confirmed that it exerts significant weightloss and fatreducing effects with favorable safety profiles.In a mouse model of highfat dietinduced obesity, administration of 20 mg/kg NNMTi daily for 11 days resulted in a significant reduction in body weight

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