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The pathophysiology of both FGIDs is based on a combination of motility disturbances, visceral hypersensitivity, low grade mucosal immune activation, and altered processing of gut-brain-signals

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Unlike topical self-tanners (which work through surface chemistry rather than melanogenesis) or topical melanocortin formulations (which have limited dermal penetration), intranasal delivery achieves systemic distribution and authentic eumelanin production