More recently, urea-based and pyrazolidine CypD inhibitors with nanomolar affinity have shown robust protection of pancreatic mitochondria and tissue architecture in cerulein- and bile acid-induced AP, confirming that mPTP inhibition is a druggable node that functionally stabilizes mitochondrialER Ca 2+ crosstalk, ROS generation, and cell-death patterns
Archives of Internal Medicine, 130(5), 778-780
Similarly, in metabolic dysfunction-associated steatotic liver disease (MASLD), GLP-1R agonists resolve hepatic steatosis by promoting healthy MERCS dynamics, thereby optimizing fatty acid oxidation (Lee et al., 2012) ( Figure 2 )
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