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Alex Tatem, a board-certified urologist and member of Rugiet's Medical Advisory Board, will testify at this week's FDA hearings

Theres no universal answer but heres the honest framework: Tirzepatide may be the better fit if: Maximum weight loss is the primary goal You have type 2 diabetes with A1c that needs significant reduction You struggled with GI side effects on semaglutide Insulin resistance is a major factor in your metabolic picture Semaglutide may be the better fit if: You have established cardiovascular disease (proven CV outcome data) You have chronic kidney disease with type 2 diabetes (2025 FDA approval) Youve responded well to semaglutide previously Cost or access is a significant barrier and compounded semaglutide is available through your provider If youve hit a plateau on semaglutide, heres why that happens and what to do next

Improves cardiovascular function and protects against heart disease