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Similarly, in Kctd13 (a gene within 16p11.2 CNV) haploinsufficient and knockout mice, there was an increase in RhoA expression coupled with deficiencies in synaptic signalingan effect that was ameliorated with Rhosin treatment [137]

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As described above, the role of charge-charge interactions is as important as 4.76% (2/42, supplementary file 4zgm.ic ) in the stabilization of the semaglutide backbone in complex with the extracellular domain (ECD) of GLP-1R (PDB ID: 4ZGM [29]), including only a few interfacial salt bridges (Table 1) and hydrogen bonds (Table 2)

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