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Experimental evidence confirms that the synthetic TGR5 agonist INT-777 confers cardioprotection and enhances myocardial function through targeted receptor activation ( Beyond facilitating lipid digestion and absorption, bile acids activate the Farnesoid X Receptor (FXR)a ligand-dependent nuclear receptor transcription factor that orchestrates bile acid, lipid, and glucose homeostasis ( TMAO Trimethylamine N-oxide (TMAO) biosynthesis originates from gut microbial metabolism of dietary precursors including choline and L-carnitine

Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor

2.7 ELISA tests for inflammation marker assay Specific rat ELISA kits from SunLong Biotech Co., Ltd., Hangzhou City, Zhejiang, China (catalog numbers SL0722Ra, SL0411Ra, and SL0537Ra, respectively) were used to measure tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and NF-B in hepatic homogenates, which are key indicators of liver inflammation

By comparison, Novo Nordisks investigational oral semaglutide led to 7.3% weight loss in a similar cohort of patients