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Emerging approaches advocate for a paradigm shift, integrating multimodal biomarkers, such as neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau protein (Tau), with in vivo imaging (fMRI, and PET), AI-driven patient stratification and adaptive trial designs

Dendritic spine density was measured on primary and secondary dendrites, and spine-head width was also assessed

On the one hand, promoting mitophagy can inhibit multiple pathological behaviors of FLSs and reduce the inflammatory response induced by mtDNA and ROS (122124)

Some peptides alter the pH of the solution, potentially denaturing the other compound before it reaches your tissue