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Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: A systematic review and meta-analysis of cardiovascular outcome trials

One final consideration is that as more states establish upper payment limit (UPL) setting authority either for prescription drug affordability boards or other similar entities, it becomes increasingly possible that GLP-1s could be subject to review and UPLs across various states

Physician supervision can help manage side effects and adjust the plan when needed

5-12 However, in clinical trials, including SURMOUNT-1 for tirzepatide and STEP 1 for semaglutide, participants were permitted to remain on a given dose for up to 4 additional weeks, as needed, to allow for the dissipation of any GI AEs