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Nature Medicine

Results Bone metabolism: Five preclinical studies found GLP-1 agonists enhanced osteoblastic differentiation and increased bone formation in osteoporotic and diabetic models

Split dosing Some researchers divide their weekly dose into two smaller injections (for example, 4mg on Monday and 4mg on Thursday instead of 8mg once weekly)

GLP-1 receptor agonists augment glucose-dependent insulin release and reduce glucagon secretion and gastric emptying while inhibiting food intake and reducing body weight