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2 Experimental 2.1 Materials and apparatus Cetyltrimethylammonium bromide (98%, CTAB), triethanolamine (TEA), dimethylformamide (DMF), dimethyl sulfoxide (DMSO), hydrochloride acid (HCl), ethanol, glutathione (GSH), N-hydroxysuccinimide, tetraethyl ortho silicate (98%, TEOS), N, N-dicyclohexyl carbodiimide (DCC), mercapto propyl trimethoxy silane (MPS), dithiothreitol (DTT), citric acid, and phosphate buffer saline (PBS, pH 7.4) were prepared from Merck Company (Darmstadt, Germany)

9 Conclusion GLP-1 receptor agonists have emerged as revolutionary therapeutic agents in the treatment of T2DM and obesity, exhibiting significant effectiveness via their multi-faceted activities