doi: 10.1056/NEJMoa1411892 222 SalamunVJensterleMJanezAVrtacnik BokalE
The reviewed data show that maternal exposure to GLP-1 agonists causes reduced embryonic-fetal survival, increases in major congenital anomalies, reduced fetal weight/growth, retardation of ossification, irregular ossification and skeletal variants in mice, rats and rabbits
The most frequently reported adverse events were gastrointestinal events, including nausea, vomiting, diarrhea, constipation, or abdominal pain, which affected 79.6% of participants in the cagrilintide-semaglutide group and 39.9% of those in the placebo group
Avoiding high-fat, greasy, or spicy foods can significantly reduce gastrointestinal distress, as tirzepatide already slows gastric emptying