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Potential causes include medication interactions (particularly with diabetes medications), thyroid dysfunction, severe insulin resistance, genetic factors affecting GLP-1 receptor function, or gastrointestinal issues preventing medication absorption

Always titrate the medication according to your doctors advice and increase the dosage slowly to give your body adequate time to adjust

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Third, it focuses attention on the tolerability challenge: greater potency appears to come with a higher side effect burden, and the field must determine how to preserve efficacy while improving patient retention [5]