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There is a close relationship between IR/diabetes and MAFLD, the mechanisms by which IR promotes MAFLD include changes in rates of adipose tissue lipolysis and de novo lipogenesis, impaired mitochondrial fatty acid -oxidation (FAO), changes in fat distribution, and alterations in levels of adipokines and cytokines (Tilg et al., 2017

Oral Biol., 38, 547-557 8

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The MC38 murine colorectal cancer cell line (RRID: CVCL_B288) was obtained from the NIH NCI DCTD tumor repository in 2018