In erythroleukemia K562 cells, in addition to the above identified NRF2 binding ARE motif, there is also a strong association of active histone codes (such as H3K4Me3, H3K9Ac, H3K27Ac, H3K79Me2) upstream of the transcription start site (Supplementary Fig
elegans , and mammalian cells resulted in increased mitochondrial function and biogenesis, UPR mt , and antioxidant response gene expression 108,109,110
The Cytoscape classic plug-in MCODE (molecular complex detection) of Metascape can be used to discover closely connected molecular complex regions in a PPI network
Additionally, increased ChaC2 expression targets the Cadherin 1 gene (encoding E-cadherin) mutation, resulting in E-cadherin loss, increased epithelial-mesenchymal transformation and lymph node metastasis, ultimately contributing to the low differentiation of breast cancer (50)