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Indeed, most of the published papers reported an immunomodulatory activity of bromelain, with a different behavior based on a specific tissue or cell type

Blaming the FDA: The BOP argued that, since Category 1 substances are not FDA approved, that justifies blocking access in the name of safety. Fact-checked: False The FDA approval process costs billions, which is why the vast majority of non-patentable natural compounds are not FDA approved