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Peptide-based approaches can target both types of tolerance

A meta-analysis of 10 prospective clinical studies on the treatment of SIBO patients with non-systemic antibiotics showed that the normalization rate of breath test in the antibiotic group was higher than that in the placebo group, indicating the effectiveness of antibiotics in regulating the flora [153]

Another study in Diabetologia went further, testing the effects of different fatty acid types on GLP-1 in humans during a hyperglycaemic clamp

Most clinical investigations conducted to date involve small pilot or open-label studies, highlighting a pressing need for larger, rigorously controlled trials to establish optimal dosing, treatment duration, and therapeutic efficacy in patients (Shahpiri et al., 2016