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References Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetesstate-of-the-art

Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol