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It has been proven that the native peptide GLP-1, GLP-1 receptor agonists and GIP-1 receptor agonists can cross the blood-brain barrier (BBB) (5761)

Combining it with other serotonergic medications such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, and certain migraine medications can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by symptoms like agitation, hallucinations, rapid heart rate, fever, excessive sweating, shivering, and diarrhoea

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