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Assembly and function of the anthrax toxin protein translocation complex

As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

One of the most commonly cited trials (Arjinpathana & Asawanonda, 2012) used 500mg per day over 4 weeks and reported a significant reduction in melanin index versus placebo