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A retinoid-naive person in their forties with significant photoaging may still benefit most from tretinoin, but starting with GHK-Cu for a few weeks to build tolerance is a sensible on-ramp

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(2025b, December 1)

The study was funded by the National Institutes of Health (grants R01DK125260, P30DK116074, K99AR081618 and GM113854), the SPARK Translational Research Program at Stanford, Stanford Bio-X, the Stanford Maternal and Child Health Research Institute, the American Heart Association, a Stanford Medicine Dean's Fellowship Award, the Carlsberg Foundation, and the Wu Tsai Human Performance Alliance