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-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

Evaluation of Plasma Trace Elements and Oxidant/Antioxidant Status in Boerboel Dogs with Hip Dysplasia

Early passage ARPE-19 cells were used as a negative control

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