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Because of these issues, methimazole generally isnt used long-term which leads to thyroidectomy (thyroid removal) or RAI (ablation of the thyroid gland)

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In clinical GLP-1 guidelines, the 2.4 mg strength is universally recognized as the final destination. It is the **therapeutic maintenance plateau**. It is explicitly not a starter dose. After your body adapts during the 0.25mg, 0.5mg, 1mg, and 1.7mg introductory periods, switching to the 2.4 mg pen provides the consistent, deep receptor saturation required to maintain your weight loss achievements indefinitely and permanently recondition your long-term metabolic health