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Bottom line: Employer-sponsored plans can carve out weight-loss drugs, and this is not appealable through Aetna FAQ Does Aetna Cover Semaglutide for Prediabetes

The door is closed

Glucagon receptor activation is thought to increase energy expenditure and promote hepatic fat oxidation, potentially contributing to the substantial weight loss observed in early trials

Weight Regain Timeline and Metabolic Changes After Stopping Clinical data shows that approximately 50-70% of weight lost on GLP-1 therapy returns within 12 months of discontinuation, though this range varies widely based on lifestyle adherence and genetic factors