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The proactive arm governs proteome production and maturation, translation, co-translational quality control, chaperone-assisted folding, trafficking, and compartment-specific targeting, thereby limiting the generation of metastable or mislocalized proteins (Fig

19: Chiang GC, Mao X, Kang G, Chang E, Pandya S, Vallabhajosula S, Isaacson R, Ravdin LD (2017)

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Advisory Committee member Kevin Zacharoff, an anesthesiologist, and clinical assistant professor at the Renaissance School of School of Medicine at Stony Brook University, explained his vote against the substance