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ONWARDS 5 (NCT04760626) Supported by: Study funding: Supported by Novo Nordisk A/S

Slides were mounted with Mowiol 488 (Merck) and images acquired with a Zeiss Axio Imager A2 fluorescence microscope

Powerful prescription GLP-1 medication with FDA-approved Wegovy When combined with healthy nutrition and a strength training routine, prescription GLP-1s can be a safe and effective tool for those looking to achieve their weight goals, better manage their weight during life changes, and address weight-related concerns due to other health conditions

GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation