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The second is a consumer perception study done on 104 participants (61 women and 43 men, ages 21 to 70) in which volunteers applied a serum that contained palmitoyl tetrapeptide-20 amide once a day

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Several papers describe upregulation of the vascular endothelial growth factor receptor 2 ( VEGFR2 ) pathway and downstream nitric oxide signalling the so-called VEGFR2-Akt-eNOS axis which researchers hypothesise underlies its reported influence on wound healing and blood-flow restoration at an injury site