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Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (55)

SCANPY: large-scale single-cell gene expression data analysis

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The bulk of BPC-157's most reproducible preclinical evidence is, fittingly, in the gut: reduction of gastric ulcers, protection of the intestinal mucosa, and effects on gut integrity