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We find that wild-type Drosophila show a striking age-dependent increase in APAP-induced mortality (Fig

Sciatic nerves were analyzed for oxidative stress markers (GSH, SOD, MDA), inflammatory cytokines (TNF, IL6), apoptotic regulators (Caspase3, BAX, Bcl2), and signaling proteins (SIRT1, AMPK, PI3K, AKT, mTOR)

Similar results were reported in a previous study, which used another type of senolytic, ABT263, to treat chondrocytes isolated from osteoarthritic cartilage (Yang et al., 2020)

This comprehensive review synthesizes findings from network pharmacology, in vitro and in vivo studies, and clinical trials to evaluate the role of natural products in AD treatment