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Patients should never discontinue or adjust medications without provider guidance, as abrupt changes can lead to worsening or uncontrolled blood pressure or loss of glycemic control

Cell culture and animals The Caco-2 cell line (human colorectal adenocarcinoma epithelial cells) and MDCK cell line (MadinDarby canine kidney cells) were acquired from American Type Culture Collection (Manassas, VA, USA)

Individuals with a personal or family history of medullary thyroid carcinoma or MEN2 are typically excluded from trials due to precautionary class-effect concerns

Where the research is specific, we say so and where it is not, we say that too