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STEP-5 (N=304) extended semaglutide 2.4 mg treatment to 104 weeks and found mean weight loss of 15.2% at two years with no plateau visible in the active arm [11]

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However, the medication's gastrointestinal side effectsparticularly nausea, vomiting, and diarrhoeacan potentially lead to dehydration, a well-recognised risk factor for kidney stones