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Best First-Line Option: Polyethylene glycol is generally considered the safest first-line option for GLP-1-related constipation

Moreover, expression of GLP-2 may be observed in the colon, although to a lesser extent than in the terminal ileum (Yusta et al

Since -glucan is degraded in the large intestine and is metabolized by the gut microbiota it significantly decreases the ratio of Firmicutes to Bacteroidetes at the phylum level, it selectively promotes the growth of Bifidobacterium , specifically Bifidobacterium longum and Lactobacillus plantarum [42, 64]

Like any medication, it may have potential side effects, which will be discussed with you by your healthcare provider