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It does this in a context-dependent way, responding to local tissue needs rather than ramping up growth signals everywhere

Since oxidative stress is closely linked to DNA damage, the study also examined the extent of DNA lesions by quantifying H2AX, a marker of DNA double-strand breaks

For xenograft studies, animals were allocated into groups ensuring the mean, median and standard error of tumor size was similar across all groups

Nrf2 inhibitors also sensitize cancers to the effects of chemotherapeutic drugs through the down-regulation of detoxification enzymes and drug excretion transporters (Singh et al., 2008