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The drug has been associated with several potentially severe side effects, such as pancreatic inflammation, thyroid cancer, kidney failure, and diabetic retinopathy

Tanser AR, Bourke MP, & Blandford AG (1973) Isocyanate asthma: respiratory symptoms caused by diphenylmethane di-isocyanate

[2] [3] GIP and GLP-1 are released from the intestine in response to food intake and play crucial roles in glucose homeostasis

Research from lifestyle-based weight loss and bariatric surgery consistently shows that weight loss can increase bone turnover and contribute to bone loss, especially in older adults and postmenopausal women