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It's been purified by distillation or equivalent methods, stripping out pyrogens (fever-causing substances), particles, and microbial contamination

Cell-culture time courses Cell-culture studies in tendon-derived and fibroblast cell populations report observable changes in cellular migration, proliferation kinetics and gene-expression in growth-factor pathways over a window of hours to several days

It also does not mean it has been proven safe or effective for every use being promoted

For purposes of estimating outlier payments for CY 2026, we used the hospital-specific overall ancillary CCRs available in the April 2025 update to the Outpatient Provider-Specific File (OPSF)