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L-Nle was preferred in the N-terminal for optimal inhibition and zinc coordination to the oxygen of the benzamide function is estimated to allow the lipophilic P1 substituent to be easily accommodated in the S1 pocket

Mild glutathione deficiency results in hemolytic anemia or destruction of the red blood cells and symptoms such as confusion, weakness, fever, and dizziness

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However, the possibility of heart palpitations as a side effect raises an important question: do these benefits outweigh the risks