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A 2021 study published in Obesity found that adding structured resistance training to GLP-1 receptor agonist treatment significantly attenuated lean mass loss compared to medication alone, with the exercise group preserving approximately 93 percent of their lean mass versus 78 percent in the medication-only group (Lundgren JR et al., Obesity, 2021, Designing a GLP-1 Cut for Bodybuilders If youre going to use compounded semaglutide or a similar medication during a cutting phase, the protocol needs to reflect your training goals, not just generic weight loss guidance
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The researchers found that the estimated mean change in hemoglobin A1c (HbA1c) after 40 weeks was 1.8, 1.5, and 0.1 percentage points for cagrilintide-semaglutide 2.4 mg each, 1.0 mg each, and placebo, respectively
[DOI] [PubMed] [Google Scholar] 13.Perakakis N, Kokkinos A, Peradze N, Tentolouris N, Ghaly W, Pilitsi E, et al
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