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Decreased levels of the reduced form of GSH in T2DM correlated with a significant increase in the levels of MDA in the plasma ( Figure 3B ) and RBCs ( Figure 3C ) from T2DM subjects when compared to healthy subjects

Male infertility is often linked to poor sperm quality, commonly caused by oxidative stress

Overall, the core molecular machinery of ferroptosis is regulated by various cellular signalling pathways and genes but is primarily mediated through two main pathways, namely, extrinsic or transporter-dependent pathways (e.g., reduced cysteine or glutamine uptake and increased iron uptake) and intrinsic or enzyme-regulated pathways (e.g., inhibition of glutathione (GSH) peroxidase 4 (GPX4) antioxidant system) (Fig

SOD, Superoxide Dismutase