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Freezing and thawing can damage the peptide structure

Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans

Selective activation of paraventricular hypothalamic nucleus MC 4 receptor neurons or MC receptor terminals in the lateral parabrachial nucleus potently suppresses feeding behaviour independent of illnessassociated appetite or aversion correlated with calcitonin generelated peptide expressing neurons in the lateral parabrachial nucleus (Garfield et al., 2015

[DOI] [PubMed] [Google Scholar] Soliman MM, Aldhahrani A, Alkhedaide A, Nassan MA, Althobaiti F, Mohamed WA