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Beyond its approved indication, PT-141 has been investigated and used off-label for male erectile dysfunction, particularly in men who don't respond to PDE5 inhibitors or have contraindications to their use

10.1016/j.mod.2015.07.007 Mech

Constipation: common but manageable Constipation is frequently reported with GLP-1 therapy and may worsen with: Low fibre intake Reduced food intake Inadequate hydration A sedentary lifestyle Helpful measures may include: Adequate water intake Fibre-rich fruits and vegetables Walking or light physical activity Isabgol or fibre supplementation if medically appropriate To reduce nausea, many patients find relief by switching to lighter regional Indian meals and smaller portions during the first few weeks

In that study, DPP-4 inhibitors caused an 8-fold increase in insulin content and an increase in the number of small islets and -cells [42]