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its half maximal inhibitory concentration (IC 50 ) was determined subsequently to be 1.2 nM (Fig

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8 Clinical positioning and pathways: risk-stratified decision matrix 8.1 Bridging gap between evidence and guidelines Traditional stepped care for PCOS-related infertility typically positions lifestyle intervention as the first-line therapy, followed by ovulation induction (OI) with letrozole or clomiphene, and ultimately ART