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Ozempic will be prescribed based on an assessment of the patients overall health, weight loss history, and any underlying medical conditions

Rabbit anti-GLP-1R, PKA, phospho-PKA (Thr197), CREB, phospho-CREB (Ser 133), tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6 primary antibodies were purchased from Abcam (Cambridge, UK)

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3.3 Metabolic modulation and immunomodulatory effects The close relationship between BMI, metabolic dysfunction, and immune activation has important implications for the potential use of GLP-1Ras in obese patients with PsA