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Compared to traditional inhibitors that directly target activated NSPs, DPP1 inhibitors act on the upstream critical link of NSP activation, providing more comprehensive and fundamental inhibitory effects (Figure 1

Maintaining a sterile environment is crucial when reconstituting these compounds for in-vitro application

Increased prevalence of proliferative retinopathy in patients with acromegaly

Overall, our findings suggest that both intrinsic and extrinsic factors contribute to CAR T cell functionality post-infusion, including a cross-talk between microenvironmental nutrients and the CAR T cell immunometabolic state in patients